Title
Hemocompatibility of cellulose-based paper coated with heparin
Authors
WEN-ZHI LV ZHU LONG MEI-YAN WU XIAO-FAN ZHOU and BIN WANG

Received July 20, 2016
Published Volume 52 Issue 3-4 March-April
Keywords cellulose-based paper, heparin, hemocompatibility, surface coating, drug loaded nanoparticles

Abstract
Heparin was coated onto the surface of cellulose-based paper either directly (Paper-Hep) or through polyurethane drug loaded nanoparticles (Paper-PU-Hep), and the hemocompatibility of these two resulting materials was examined through in vitro anticoagulation tests, hemolysis tests and blood adhesion tests. It was found that loading with heparin significantly improved the hemocompatibility of the paper. Loading the heparin with polyurethane nanoparticles to the paper matrix rendered milder and more persistent anticoagulation efficacy in Paper-PU-Hep, compared with Paper-Hep, for which heparin was loaded plainly through physical adsorption.