Title
Enalapril maleate loaded pullulan film for mucoadhesive buccal drug delivery applications
Authors
SIMONA GHERMAN DANIELA ZAVASTIN LACRAMIOARA OCHIUZ GABRIELA BILIUTA and SERGIU COSERI

Received Paper dedicated to the 50^{th anniversary of the Cellulose Chemistry and Technology journal}
Published Volume 50 Issue 5-6 May-June
Keywords pullulan, enalapril maleate, buccal film, drug delivery

Abstract
Pullulan, a water soluble, bioadhesive and biocompatible biopolymer is used as an efficient matrix for enalapril maleate film preparation. The obtained film contains as much as 67% of enalapril maleate, relative to the initial amount used for experiments. The drug content was evaluated by using 1H-NMR and UV-vis spectroscopy. The pullulan enalaprilmaleate blends exhibit good physicochemical properties, as well as a high dissolution rate, which makes these formulations usable as mucoadhesivebuccal film.