Title
Xanthan-chitosan complex as a potential protector against injurious effects of neomycin
Authors
IRINA-PAULA MERLUSCA PETRU PLAMADEALA CATALINA GIRBEA and IONEL MARCEL POPA

Published Volume 50 Issue 5-6 May-June
Keywords xanthan, chitosan, neomycin, protector

Abstract
The aim of this paper was to achieve neomycin sulphate (Ne) inclusion using a hydrophilic xanthan-chitosan polyionic complex (Xa-Cs) to develop an oral controlled release drug delivery system and a potential protector against injurious effect of Ne. The obtained samples were characterized by FT-IR spectroscopy, SEM microscopy and the study of the swelling behavior in simulated gastric fluid (pH = 2.0) and intestinal fluid (pH = 7.2). An in vivo study was conducted on healthy wistar rats. The drug dose chosen for in vivo study was 50mg Ne/100g body weight or an equivalent dose in complex form. The treatment with Xa-Cs-Ne ameliorated the biochemical parameters (creatinine, urea, serum uric acid and C-reactive protein levels) and histological changes of colon due to drug toxicity.