Title
Antifungal cotton fabric via molecular encapsulation of terbinafine
Authors
GOKHAN ERKAN MERIH SARIISIK and NURDAN KASIKARA PAZARLIOGLU

Received September 14, 2012
Published Volume 48 Issue 7-8 July-August
Keywords terbinafine, monochlorotriazine-β-cyclodextrin, cotton fabric, spray drying, kneading

Abstract
The aim of the study was to investigate inclusion complex formation of terbinafine, an allylamine based antifungal pharmaceutical agent, by spray drying and kneading, and its grafting onto cotton fabric. Terbinafine was introduced in monochlorotriazine-beta-cyclodextrin in 3 different molar ratios. The products were obtained by spray drying and kneading. The products were analyzed by X-ray diffractometry, differential scanning calorimetry and FTIR spectroscopy. Terbinafine and monochlorotriazine-beta-cyclodextrin in 1:3 molar ratio presented evidence of inclusion complex formation by both spray drying and kneading methods. The inclusion complex was applied to 100% cotton fabric by the padding method. Then the fabric was subjected to different numbers of washing cycles. N percentage of the fabrics was determined by C, H, N, S elemental analysis to evaluate washing durability. Antifungal strength against Trichophyton rubrum was observed even after 15 washing cycles.